How about refrigerated? These are common questions from patients received antibiotic suspensions which "constitutes" our question of the week. Which of the following correctly matches its storage and stability after reconstitution?
Select all that apply. As pharmacists, it is essential to know the storage and stability of medications after reconstitution, as they are important counseling points when dispensing to patients. Each formulation has specific recommendations and you should consult the package insert for detailed storage and stability information. Answer A is incorrect because amoxicillin suspension is stable for 14 days at room temperature or refrigerated. Refrigeration is often preferred, and can sometimes taste better for pediatric patients when stored in the refrigerator.
Unit-dose antibiotic oral syringes are stable at room temperature for at least 72 hours. Answer B is correct. Unit-dose antibiotic oral syringes are stable under refrigeration for 24 hours. Answer C is correct. However, it is important to note that there are different instructions for azithromycin extended release suspension Zmax. The suspension should not be refrigerated, and it should be consumed within 12 hours following reconstitution. Answer D is incorrect because cefdinir suspension should be stored at room temperature and discarded after 10 days.
Answer E is correct. Clindamycin solution should be stored at room temperature for up to 2 weeks 14 days after reconstitution. It should not be refrigerated as the solution will thicken. Forms of liquid amoxicillin for children:. Once made up, the amoxicillin solution usually has 7 days shelf life.
However, some sugar-free versions of amoxicillin solution for children have a shelf life of 14 days. Please check for expiry dates on the bottle of the product. Co-amoxiclav oral solution is also known under a brand name Augmentin. Co-amoxiclav and Augmentin come in the following strengths:.
Phenoxymethylpenicillin is available as sugar-free and sugar version and comes in two different strengths:. The sugar-free and sugared version of phenoxy antibiotic solution for children has a shelf life of 7 days once made up.
Cefalexin liquid antibiotic is available in generic form and as branded medicine called Keflex. Cefalexin comes in two different strength formulations:. Keflex a branded form of cefalexin oral suspension should be used within 10 days after reconstitution. Erythromycin liquid comes in a variety of preparations, including sugar and sugar-free liquid forms.
There are some differences in storage recommendations between various forms of liquid erythromycin antibiotics. Some sugar-free versions of erythromycin for example, Erythroped do not have specific storage recommendations. Once made up, a solution can be kept at room temperature. Erythroped is not commonly dispensed in community pharmacies.
Once made up, all preparations of erythromycin sugar-free and sugar have a shelf life of 14 days. Erythroped a branded version of erythromycin has a shelf life of 7 days.
Once made up, both reconstituted suspensions can be kept at room temperature. Do you have to refrigerate Trimethoprim liquid antibiotic? There is no specific storage recommendation for Trimethoprim liquid antibiotics. Once opened, Trimethoprim can be stored at room temperature.
Trimethoprim suspension for children expiry date Product information for trimethoprim oral suspension does not specify any expiry dates once the suspension is open.
This usually means that the product should not be used after the expiry date stated on the label or box.
Metronidazole comes as a ready-made solution. How to store Metronidazole oral solution? Metronidazole oral solution can be stored at room temperature. Metronidazole oral solution expiry date Metronidazole oral solution should not be used after the expiry date, which is stated on the label and the box. Product information leaflets for all liquid antibiotics can be accessed on EMC website. Amoxicillin has a shelf life of 7 days.
Some sugar-free versions of amoxicillin solution have 14 days shelf life. Stanley S. View Article Download Cite Statistics Share Abstract Antibiotics for pediatric use are commonly available as dry powders for reconstitution into oral suspensions. Keywords: Antibiotics degradation oral suspension reconstitution stability storage.
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